Migraine clinical trials are research studies that test new treatments for migraine and chronic headache, and many compensate participants for their time. In the UK, these studies are run by the NHS, universities and private research units, all regulated by the MHRA. This guide explains who can take part, what you can earn, and how to find a genuine study safely.
Who is this guide for?
This guide is for people who experience migraine or chronic headaches and are interested in research studies, as well as anyone wanting to understand how migraine trials work, eligibility, and how to apply through legitimate channels.
What are migraine clinical trials?
Migraine clinical trials are controlled studies that test new ways to prevent or treat migraine. They may involve new preventive medications, acute treatments taken during an attack, injectable therapies such as CGRP inhibitors, devices, or lifestyle interventions. Some studies recruit people with frequent or chronic migraine; others focus on occasional or episodic migraine.
Who can take part in a migraine trial?
Eligibility depends on the specific study. Common criteria include:
- A diagnosis of migraine, with a minimum number of attacks per month
- Being within a certain age range
- Whether your migraine is episodic or chronic
- Previous treatments tried
- General health and other medical conditions
Each trial has its own inclusion and exclusion criteria, set out in the participant information sheet before you consent.
Do migraine clinical trials pay?
Many do. Compensation depends on the study, its length and the number of visits:
- Outpatient visits: £50–£200 per visit
- Longer studies with regular visits: several hundred pounds or more
Some NHS and university migraine studies cover travel expenses only. For how payment works generally, see our guide to the best-paid clinical trials.
How do you find a migraine clinical trial?
- Search a registered source. Use the UK’s Be Part of Research service or the WHO registry.
- Check migraine charities. Organisations such as The Migraine Trust share research opportunities.
- Speak to your GP or neurologist. They may know of suitable studies.
- Read the participant information sheet for what’s involved, any compensation, and your right to withdraw.
Are migraine clinical trials safe?
UK migraine trials operate under strict safeguards: every study must be authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) and approved by an independent research ethics committee, as the NHS explains. You are monitored by medical staff throughout and can withdraw at any time, without giving a reason. Our guide to clinical trial safety and compensation covers the protections in more depth.
The bottom line
Migraine clinical trials offer access to new treatments and the chance to contribute to research, often with compensation for your time. Use a registered source, confirm the study is MHRA-approved, never pay to take part, and read the information sheet before you consent.
Frequently Asked Questions
Do migraine clinical trials pay?
Many do, typically £50–£200 per visit or more for studies with regular visits. Some NHS and university studies cover expenses only.
How many migraines do I need to qualify?
It varies. Many studies set a minimum number of migraine days per month, and some specifically recruit people with chronic migraine. The criteria will state the requirement.
Can I join a migraine trial if I take preventive medication?
It depends on the study. Some recruit people already on treatment; others require you not to be, or to stop for a period. The criteria will make this clear.
Are migraine clinical trials safe?
Yes. They are MHRA-authorised, ethics-approved and medically supervised throughout. You can withdraw at any time.
How do I find a migraine trial near me?
Use the NHS Be Part of Research service, check The Migraine Trust, ask your GP or neurologist, or compare studies through CheckMyTrial.
Find clinical trials near you
CheckMyTrial helps you compare clinical trials across the UK by location, condition and study type. Browse current trials or read how clinical trials work before you apply.